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Rapha, Joanne, Iago e Fred discutem os principais argumentos a favor do tratamento precoce e as evidências sobre as principais medicações. Para saber mais sobre nosso curso, entra lá no @tadeclinicagem ou cursotdc.com.br
Minutagem
(0:35) Curso TdC
(3:55) Tratamento precoce COVID-19
(6:00) Fatores que fazem o paciente melhorar sem medicamentos
(8:02) Experiências pessoais
(10:15) Viés de confirmação
(10:40) Reversão médica
(15:30) Ônus da prova
(18:30) Falácia ecológica
(20:50) Mecanicismo
(24:20) Hidroxicloroquina
(30:36) Ivermectina
(40:20) Corticoide
(42:36) Azitromicina
(44:00) Anticoagulação
(47:08) Vitaminas
(55:23) Nova droga
(58:28) Covid na Prática
(1:00:30) Mensagem final
(1:02:50) Salves
(1:05:40) Desafio da semana anterior
(1:06:34) Desafio da semana
Referências:
1- HARTMAN, Steve E. Why do ineffective treatments seem helpful? A brief review. Chiropractic & osteopathy, v. 17, n. 1, p. 1-7, 2009.
2- ROCCO, Patricia RM et al. Early use of nitazoxanide in mild Covid-19 disease: randomised, placebo-controlled trial. European Respiratory Journal, 2020.
3- https://twitter.com/azavascki/status/1319732851273797632
4- HASTIE, Claire E. et al. Vitamin D concentrations and COVID-19 infection in UK Biobank. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, v. 14, n. 4, p. 561-565, 2020.
5- MELTZER, David O. et al. Association of vitamin D status and other clinical characteristics with COVID-19 test results. JAMA network open, v. 3, n. 9, p. e2019722-e2019722, 2020.
6- MURAI, Igor H. et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: a randomized clinical trial. Jama, v. 325, n. 11, p. 1053-1060, 2021.
7- VIMALESWARAN, Karani S.; FOROUHI, Nita G.; KHUNTI, Kamlesh. Vitamin D and covid-19. 2021.
8- https://clinicaltrials.gov/ct2/show/NCT04344041
9- https://clinicaltrials.gov/ct2/show/NCT04579640
10- COVID-19 rapid guideline: vitamin D. NICE Guideline (NG 187). 17/12/2020. Disponível em: https://www.nice.org.uk/guidance/ng187
11- CASTILLO, Marta Entrenas et al. Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study. The Journal of steroid biochemistry and molecular biology, v. 203, p. 105751, 2020.
12- Adam Cuker, Flora Peyvandi COVID-19 Hipercoagulability. Acesso em uptodate.com em 03/04/21
13 - LÓPEZ-MEDINA, Eduardo et al. Effect of ivermectin on time to resolution of symptoms among adults with mild COVID-19: a randomized clinical trial. Jama, 2021
14 - WORLD HEALTH ORGANIZATION et al. Therapeutics and COVID-19: living guideline, 31 March 2021. World Health Organization, 2021.
15 - THOMAS, Suma et al. Effect of high-dose zinc and ascorbic acid supplementation vs usual care on symptom length and reduction among ambulatory patients with SARS-CoV-2 infection: the COVID A to Z randomized clinical trial. JAMA network open, v. 4, n. 2, p. e210369-e210369, 2021.
16 - CALY, Leon et al. The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral research, v. 178, p. 104787, 2020.
17 - GROUP, The RECOVERY Collaborative. Dexamethasone in hospitalized patients with Covid-19—preliminary report. The New England journal of medicine, 2020.